Decoding Protein Folding: A 3D Infographic Journey

canvas: "Scientific Editorial Infographic"
global_style: "Ultra-realistic 3D, precise macro lighting, shallow DOF, structural biology aesthetic"
title: "FOLD: THE ENERGY LANDSCAPE OF [$PROTEIN]"

layout_engine:
  type: "Multi-Basin Free-Energy Landscape"
  connectors: "Conformational transition paths with Gibbs gradient contours"
  frame_shape: "Funnel + side-basin topology (native basin + kinetic traps)"
  flow_direction: "High-entropy ensemble → folded basin(s) → off-pathway kinetic traps"

frames:
  f1_unfolded:
    size: "xs"
    content: "Semantic inference of [$PROTEIN] unfolded ensemble: heterogeneous, high-entropy conformers"
    ui_label: "Unfolded | High entropy | Conformational ensemble"

  f2_secondary:
    size: "s"
    content: "Semantic inference of [$PROTEIN] early local structure formation: transient helices, sheets, turns"
    ui_label: "Secondary | Local structure | Backbone H-bond emergence"

  f3_intermediate:
    size: "m"
    content: "Semantic inference of [$PROTEIN] folding intermediates: partially collapsed, non-native contacts"
    ui_label: "Intermediate | Molten-globule | Multi-pathway basin"

  f4_native:
    size: "l"
    content: "Semantic inference of [$PROTEIN] functional conformation: stable basin, correct topology"
    ui_label: "Native | Functional basin | Lowest accessible ΔG"

  f5_misfolded:
    size: "xl"
    content: "Semantic inference of [$PROTEIN] off-pathway misfolding: β-rich aggregates, fibrils, or amorphous states"
    ui_label: "Misfolded | Kinetic trap | Off-pathway aggregation"

side_panel:
  "RMSD-to-native trends, ΔG basin depths, structural icons (helix, sheet, loop, aggregate), pathway arrows"

halo_details:
  "Ramachandran overlays, hydrophobicity heatmaps, phi/psi distributions, frustration hotspots.
   Reject generic DNA helices, pill bottles, or non-protein artifacts."